Using Psilocybin to Overcome Smoking Addiction
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The most comprehensive insights into psilocybin's potential to combat nicotine addiction have been derived from a study conducted at Johns Hopkins University in Baltimore under the leadership of Professor Roland Griffiths.
Griffiths and his research team chose to explore how psilocybin could enhance conventional smoking cessation methods. In this preliminary study, they enlisted 15 smokers with an average smoking history of 31 years, consuming approximately 19 cigarettes daily. These participants underwent a 15-week smoking cessation program, incorporating a minimum of two psilocybin doses alongside weekly therapy sessions.
The participants' smoking-related biological markers, including urine levels and exhaled carbon monoxide, were assessed both during the and six months later. Additionally, they provided self-reported smoking data and underwent evaluations using the Fagerström test for cigarette dependence. Furthermore, participants completed a series of questionnaires aimed at gauging the psychological effects of their psilocybin experience.
Six months after the, 12 out of 15 participants had successfully quit smoking. Among the three participants who continued to smoke, two had significantly reduced their smoking levels. Remarkably, only one participant in the entire study didn't perceive a positive impact of psilocybin on their smoking cessation efforts.
This 80% success rate stands out significantly when compared to conventional smoking cessation methods, like therapy alone, which typically achieve a success rate of 35% at most. A standard twelve-week smoking cessation program results in approximately 17% abstinence after six months. Even therapy programs incorporating medications like bupropion and Varenicline achieve success rates of only 24-35% after the same period.
In this study, researchers conducted extended follow-ups to assess the long-term effectiveness of psilocybin for tobacco addiction. Two follow-ups were conducted after the initial: one at 12 months and another at a longer-term period, averaging 30 months but at least 16 months post-. During these follow-ups, participants were assessed using the same biomarkers as before to confirm their reported smoking abstinence. At the 12-month mark, 10 out of 15 participants remained abstinent, and at the longer-term follow-up, 9 out of 12 participants were still smoke-free. These outcomes are notably impressive when compared to traditional smoking cessation methods, which typically exhibit around a 30% success rate at the 12-month mark.
According to Griffiths and his team, the effectiveness of their heavily relied on careful crafting an optimal psilocybin experience, supported by extensive expertise in psychedelic.